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Tatyana Dobreva, Ph.D. Thesis Defense

Monday, August 30, 2021
11:00am to 12:00pm
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Engineering tools to probe and manipulate the immune system at single-cell resolution
Tatyana Dobreva, Ph.D. Student, Department of Medical Engineering, California Institute of Technology,

https://caltech.zoom.us/j/89893552024

My research focuses on developing experimental and computational tools to probe and manipulate cellular transcriptomes in the context of human health and disease. For probing cellular transcriptome states, I have leveraged single-cell RNA sequencing (scRNA-seq) to understand human immune variability, characterize cell-type specific biases of multiple viral variants within an animal, and assess temporal immune response in the brain to delivery of genetic cargo via an adeno-associated virus (AAV). In the context of manipulating cells, I have made progress on tools for exporting RNA extracellularly and engineering of a transcription factor for modulating macrophage state.

For more information, please contact Christine Garske by email at ccgarske@caltech.edu or visit https://mede.caltech.edu/seminars/thesis.